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2).6 The lesions disappear spontaneously after a few years, and it is rare to find them in late childhood and early adulthood.7 Their estimated prevalence in patients with NF1 ranges from 0.7% in adults8 to 37.5% in children,7 and these lesions are particularly common in children aged less than 9 years.4,7 In our series, the prevalence of JXGs in pediatric patients with definite diagnosis of NF1 was 6.2%,5 a figure that approximates the 8.5% reported by other authors.3 In any case, it cannot be denied that JXG is a significant finding in patients with NF1, and it can be of particular importance in cases with no definitive diagnosis

Furthermore, serious adverse effects have not been elucidated in depth